4-Nitrophenetole, with the CAS number 100-29-8, is an organic compound characterized by the presence of both a nitro group and a phenolic ether structure. It features a nitro group (-NO2) attached to the para position of a phenol ring, which is further substituted with an ethyl group. This compound typically appears as a yellow crystalline solid and is known for its moderate solubility in organic solvents, while being less soluble in water. 4-Nitrophenetole exhibits properties such as being a weak acid due to the phenolic hydroxyl group, and it can participate in various chemical reactions, including nucleophilic substitutions and electrophilic aromatic substitutions. Its nitro group contributes to its reactivity and potential applications in organic synthesis, as well as in the production of dyes and pharmaceuticals. Additionally, safety considerations are important, as nitro compounds can be hazardous, necessitating proper handling and storage protocols.

4-nitrophenetole

100-29-8: 1-Ethoxy-4-nitrobenzene, 4-Ethoxy-1-nitrobenzene, 4-Ethoxynitrobenzene, 4-Nitrophenetol, 4-Nitrophenyl ethyl ether, Ai3-00233, Benzene, 1-ethoxy-4-nitro-, Brn 0972473, Ccris 2333, Ethyl 4-nitrophenyl ether, Ethyl p-nitrophenyl ether, Hsdb 5333, Nsc 9812, Phenetole, p-nitro-, Phenetole, p-nitro- (8CI), p-Ethoxynitrobenzene, p-Nitrobenzene ethyl ether, p-Nitrophenetol, p-Nitrophenetol [German], p-Nitrophenetole,  4-06-00-01283 (Beilstein Handbook Reference), 4-Nitrophenetole

4-Nitrophenetole is a cell-impermeable drug that inhibits protein synthesis in bacteria by binding to the dinucleotide phosphate, which prevents the formation of an enzyme complex with the ribosomes. It is also able to inhibit wild-type strains of bacteria and is not active against recombinant virus. 4-Nitrophenetole is bacteriostatic at neutral pH and exhibits its strongest activity against wild-type bacterial strains at pH 5. It has been shown to inhibit protein synthesis in rat liver microsomes and nucleophilic enzymes such as dehydrogenases and phosphotransferases.

CAS 100-29-8: 4-nitrophenetole

4-Nitrophenetole

Ref: 3D-AAA10029

4-Nitrophenetole

Ref: 3B-N0216