Voruciclib is a small molecule inhibitor primarily targeting cyclin-dependent kinases (CDKs), particularly CDK9, which plays a crucial role in regulating transcription and cell cycle progression. This compound is part of a class of drugs designed to interfere with the activity of CDKs, thereby inhibiting cancer cell proliferation. Voruciclib has shown potential in preclinical studies for treating various types of cancers, including hematological malignancies and solid tumors. Its mechanism of action involves disrupting the phosphorylation of RNA polymerase II, leading to the downregulation of oncogenic transcription factors. Voruciclib is characterized by its specific binding affinity to CDK9, which contributes to its efficacy in cancer therapy. Additionally, it is important to consider its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, which influence its therapeutic potential and safety profile. Ongoing clinical trials are assessing its effectiveness and safety in combination with other therapies, aiming to enhance treatment outcomes for patients with resistant or advanced cancers.

Voruciclib

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Voruciclib is a small-molecule inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It inhibits the proliferation of cancer cells in vitro, as well as the growth of tumors in a mouse model. Voruciclib has been shown to have an effective dose that is well tolerated. The drug also has inhibitory effects on cellular proliferation and apoptosis pathway. Voruciclib induces apoptosis by inhibiting the expression and activity of the MCL-1 protein, which regulates cell death pathways. Voruciclib also inhibits activated CDK4/6, which are involved in the regulation of cell cycle progression.

Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.

CAS 1000023-04-0: Voruciclib

Voruciclib

Ref: 3D-FV103870

Voruciclib

Ref: TM-T10096L

Voruciclib

Ref: 54-BUP00389

Voruciclib

Ref: IN-DA0092WG