Thyrocalcitonin, also known as calcitonin, is a peptide hormone produced primarily by the parafollicular cells (C cells) of the thyroid gland. It plays a crucial role in calcium homeostasis by lowering blood calcium levels, primarily through its action on bone and kidney. The hormone inhibits osteoclast activity, which reduces bone resorption, and promotes renal excretion of calcium. Thyrocalcitonin is composed of 32 amino acids in its human form and exhibits a molecular weight characteristic of peptide hormones. It is often used therapeutically in conditions such as osteoporosis and Paget's disease, where it helps to mitigate excessive bone loss. The CAS number 100016-62-4 specifically identifies the synthetic form of calcitonin, which can be derived from various sources, including salmon, which has a higher potency than human calcitonin. In terms of stability, calcitonin is sensitive to heat and pH changes, necessitating careful handling and storage conditions to maintain its efficacy.

thyrocalcitonin

100016-62-4: Calcitonin (chicken), H-Cys-Ala-Ser-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 (Disulfide bond)

Calcitonin is a peptide hormone that regulates the metabolism of calcium and phosphate. It is synthesized by the parathyroid gland, but also found in other tissues, including the pancreas, brain, and stomach. Calcitonin was first discovered as a protein in plasma membranes of chicken cells incubated with radioactive calcitonin. The plasma membranes were then collected and assayed for calcitonin protein. Binding studies showed that calcitonin binds to receptors on the surface of cells. Dose-dependent binding curves show that calcitonin has a high affinity for its receptor. Radioligand binding studies have shown that calcitonin binds to receptors in porcine membranes as well as human erythrocytes. These results indicate that calcitonin acts through G-protein coupled receptors with an affinity similar to those of other peptide hormones such as thyrotropin-releasing hormone (TRH) and glucagon.

CAS 100016-62-4: thyrocalcitonin

Calcitonin, chicken

Ref: 3D-FC73304