KW-2449, identified by its CAS number 1000669-72-6, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule and is known to act as a selective inhibitor of certain biological pathways, which may contribute to its efficacy in treating specific diseases. The compound exhibits a unique structural framework that allows it to interact with target proteins, influencing their activity. Its solubility, stability, and bioavailability are critical characteristics that determine its pharmacokinetic profile. Additionally, KW-2449 has undergone various studies to assess its safety and toxicity, which are essential for evaluating its suitability for clinical use. As research continues, the compound's full potential and mechanisms of action are being explored, making it a subject of interest in drug development and therapeutic innovation.

KW-2449

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4-[(E)-2-(1H-Indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone is a potent inhibitor of the metabolic pathway, which can be used to study endogenous metabolites. The compound was shown in an inhibition study to inhibit the activity of piperazine and tissue metabolizing enzymes such as aldehyde oxidase, coagulation factors, and multikinase. 4-[(E)-2-(1H-Indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone inhibits these enzymes by forming a covalent bond with the enzyme's active site. This covalent bond prevents the enzyme from performing its function. The compound has shown activity against various bacterial strains, including methicillin resistant Staphylococcus aureus (MRSA).

[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone

KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.

CAS 1000669-72-6: KW-2449

[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone

Ref: 3D-FI153964

KW-2449

Ref: TM-T2341

KW-2449

Ref: 54-BUP13001

Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-

Ref: IN-DA0000SX