CAS 10018-19-6: 1,3-Dioxolo[4,5-g]isoquinolinium, 7,8-dihydro-4-methoxy-6-methyl-, chloride (1:1)

Cotarnine chloride

Cotarnine chloride is an isoquinoline alkaloid, which is a derivative of the opium alkaloid narcotine. It is synthesized through the oxidation and chlorination of narcotine extracted from opium. The mode of action of cotarnine chloride primarily involves its vasoconstrictive properties, which help in reducing blood flow by contracting smooth muscle fibers in blood vessels. This action aids in achieving hemostasis, thereby preventing or controlling hemorrhage. Cotarnine chloride has historically been used in various medical applications due to its ability to control bleeding. It has been utilized in situations involving capillary bleeding, such as gastrointestinal hemorrhages or excessive menstrual bleeding. Despite its potential effectiveness, the use of cotarnine chloride has decreased with the advent of more modern hemostatic agents that offer better safety profiles and efficacy. However, it remains a compound of interest in pharmacological research, particularly in understanding the vasoconstrictive mechanisms of isoquinoline alkaloids and their potential therapeutic applications in managing bleeding disorders.

Stability Hygroscopic Applications Cotarnine Chloride is an oxidative degradation product of the drug Noscapine. References Johansson, M., et al.: J. Pharm. Biomed. Anal., 7, 1055 (1989), Ukhin, L., et al.: Chem. Nat. Compds., 40, 156 (2004),