CAS 100276-03-7: (±)-4-(2-Chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylic acid isopropyl ester

BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.

Bay R is a carboxylic acid that inhibits the growth of fungi by disrupting the cell membrane. It is used as an anti-fungal agent and has been shown to have activity against Blastomyces dermatitidis, Histoplasma capsulatum, Aspergillus fumigatus, and Candida albicans. Bay R is also effective against avian influenza virus, which infects birds and mammals, including humans. The efficacy of Bay R for treatment of infectious diseases may be due to its ability to inhibit the synthesis of RNA in eukaryotic cells by inhibiting DNA synthesis or by binding to RNA polymerase.