CAS 100324-63-8: 25-DESACETYL RIFABUTIN

25-O-Deacetyl rifabutin is an antibiotic derivative, which is sourced from the semi-synthetic modification of rifabutin, a compound originally derived from the fermentation of the bacterium Amycolatopsis mediterranei. This derivative works by inhibiting bacterial RNA synthesis. It achieves this by specifically targeting the DNA-dependent RNA polymerase enzyme, which is essential for bacterial transcription. The mechanism involves binding to the beta-subunit of the polymerase, thereby blocking the elongation of the RNA chain, which ultimately leads to the death of the bacterial cell. The primary applications of 25-O-Deacetyl rifabutin lie in its potential use as an anti-tubercular agent. Given the increasing prevalence of resistant Mycobacterium tuberculosis strains, derivatives of rifabutin are being extensively researched for their potential to combat multi-drug resistant forms of tuberculosis. Moreover, its structure-activity relationship is also explored for optimizing efficacy and minimizing resistance development. Studies on 25-O-Deacetyl rifabutin are ongoing to ascertain its pharmacokinetic properties and to evaluate its viability as a therapeutic agent within the broader context of infectious disease control.