3'-Deoxy-3'-fluorokanamycin A is a synthetic derivative of kanamycin, an aminoglycoside antibiotic. This compound is characterized by the substitution of a fluorine atom at the 3' position of the deoxysugar moiety, which alters its biological activity and pharmacological properties compared to its parent compound. The presence of the fluorine atom enhances its stability and may improve its efficacy against certain bacterial strains, particularly those resistant to traditional aminoglycosides. Like other aminoglycosides, 3'-deoxy-3'-fluorokanamycin A functions by binding to the bacterial ribosome, inhibiting protein synthesis, and ultimately leading to bacterial cell death. Its structure includes multiple hydroxyl groups, contributing to its solubility in water and its interaction with biological systems. The compound has been studied for its potential therapeutic applications, particularly in treating infections caused by Gram-negative bacteria. However, as with many antibiotics, the emergence of resistance remains a significant concern in its clinical use.

3'-deoxy-3'-fluorokanamycin A

100343-09-7: D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-3,6-dideoxy-3-fluoro-alpha-D-glucopyranosyl-(1-4))-2-deoxy-, 4,6-Diamino-3-[(6-Amino-3,6-Dideoxy-3-Fluorohexopyranosyl)Oxy]-2-Hydroxycyclohexyl 3-Amino-3-Deoxyhexopyranoside

Kanamycin is a broad-spectrum antibiotic that inhibits the synthesis of bacterial cell walls by binding to the β-subunit of the enzyme N-acetylmuramyl-L-alanine amidase. It also inhibits the synthesis of bacterial DNA by binding to DNA gyrase and topoisomerase IV. Kanamycin has been shown to be effective against resistant bacteria, such as those that are resistant to aminoglycosides and other antibiotics. This drug can be used as an alternative treatment for bacteria that have become resistant to other drugs.

CAS 100343-09-7: 3'-deoxy-3'-fluorokanamycin A

4-Amino-2-[4,6-Diamino-3-[6-(Aminomethyl)-4-Fluoro-3,5-Dihydroxyoxan-2-Yl]Oxy-2-Hydroxycyclohexyl]Oxy-6-(Hydroxymethyl)Oxane-3,5-Dio l

Ref: 3D-FA103726