CAS 10041-02-8: 4-(1H-Imidazol-1-yl)phenol

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4-(Imidazol-1-yl)phenol

1-(4-Hydroxyphenyl)-imidazole (1HPI) is a potent inhibitor of the enzyme tyrosine phosphatase, which is necessary for cell signaling. The redox potentials of 1HPI have been determined by vibrational spectroscopy to be -0.93 V versus standard hydrogen electrode (SHE). This compound has also been shown to inhibit monoclonal antibody production and light signal generation in vitro. 1HPI has potent inhibitory activity against a number of pathogens, including Mycobacterium tuberculosis and HIV-1. Hydrogen bonding interactions with the hydroxyl group are responsible for this inhibition. The binding constants of 1HPI have been determined using electrochemical studies on microparticles containing its ligand binding site. In addition, 1HPI can be used as a sample preparation reagent for mass spectrometry analysis and other biophysical studies due to its high solubility in organic solvents.

4-(1H-Imidazol-1-yl)phenol

4-(Imidazol-1-yl)phenol is a potent signal enhancer in horseradish peroxidase (HRP)-luminol chemiluminescence (CL) immunoassays [1].