CAS: 1006711-90-5

Maleimide-DOTA is a non-cleavable linker utilized for the synthesis of antibody-drug conjugates (ADCs).

Maleimide-DOTA is a chemical conjugation agent, which is a synthetic compound used in the field of radiopharmaceutical development. It is derived from the combination of maleimide and DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). The maleimide moiety specifically reacts with thiol groups, allowing for the selective conjugation to cysteine residues of peptides or proteins. This reactivity is crucial for precise coupling in biochemical modifications, while the DOTA component serves as a versatile chelator for radiometals. The primary mode of action involves the maleimide group forming stable thioether bonds with thiol-containing molecules, enabling the attachment of the macrocyclic DOTA to target biomolecules. DOTA is particularly valued for its ability to chelate a wide range of metal ions, including those used in medical imaging and therapy, such as gadolinium, indium, or yttrium. Uses and applications of Maleimide-DOTA are centered in nuclear medicine and molecular imaging, where it facilitates the creation of targeted radiopharmaceuticals. By linking biologically active molecules with radiometal ions, it enhances the development of advanced diagnostic and therapeutic agents, contributing to personalized medicine.