CAS 100898-63-3: 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine

N4-Acetyl-2?-Deoxy-5?-O-Dmt-Cytidine

N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine is a potent and selective inhibitor of the receptor tyrosine kinases Cck-A, which is overexpressed in certain tumour cells. N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine blocks the activation of Cck-A by endothelin, thereby inhibiting the proliferation of tumour cells. This compound also has affinity for other protein kinases including receptor tyrosine kinase (RTK)s, which may be due to its tautomeric equilibrium.

5'-O-DMT-N4-Ac-dC, or compound 7, is a deoxynucleoside for making dod-DNA with hydrophobic regions.

N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine is a novel anticancer agent that is modified with a phosphoramidite. It is a nucleoside analog that selectively inhibits DNA polymerases and RNA polymerases, and therefore prevents the synthesis of DNA and RNA. N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine has been shown to be highly active against various cell lines in vitro, including human leukemia cells (HL60), human prostate cancer cells (PC3), human breast cancer cells (MCF7), and human mammary tumor cells (HTB6). This compound has also been shown to have antiestrogenic activity in vivo.