CAS 100929-99-5: phe-arg B-naphthylamide dihydrochloride

Phe-Arg-beta-NA·2HCl is a drug that acts as an inhibitor of the bacterial efflux pump. It binds to the bacterial outer membrane and blocks the active transport of a wide variety of antibiotics, including ciprofloxacin and flumequine. Phe-Arg-beta-NA·2HCl has been shown to inhibit efflux mediated by many different efflux pumps, including RND, MFS, and ABC transporters. This drug also inhibits the growth of bacteria from the genera Pseudomonas, Stenotrophomonas, Serratia, Acinetobacter, and Enterobacteriaceae.

Substrate for dipeptidyl aminopeptidase I (cathepsin C). A broad-spectrum efflux pump inhibitor in gram-negative bacteria. PAbN has been evaluated as an adjunct to antibiotics, as efflux in bacteria mediates antibiotic resistance. Vecchione et al. demonstrated that Phe-Arg-β-naphthylamide could potentiate drug activity also against a gram-positive bacterium. PAbN permeabilizes the outer membrane of gram-negative bacteria (Lamers et al.).

PAβN dihydrochloride

Applications Phe-Arg-beta-naphthylamide Dihydrochloride can be used as a reagent in organic synthesis. References Low, May L., et al.: Bioconjugate Chem., 25(12), 2269-2284 (2014)

PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.