CAS 1010-95-3: 1H-Indole-3-ethanamine, 5-methyl-, hydrochloride (1:1)

5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.

5-Methyltryptamine hydrochloride is a chemical compound that belongs to the group of amines. It is an agonist for 5-HT2 receptors. The optimum pH for this compound is between 4 and 7.5, with a ph of 6 being optimal. It has been shown to stimulate the release of acetylcholine and dopamine in the brain, as well as having effects on glomerulosa cells in the adrenal gland. 5-Methyltryptamine hydrochloride also has been shown to be a specific agonist at monoaminergic receptors in various model systems, including epidermal growth factor receptor binding and growth factor activation.

5-Methyltryptamine hydrochloride is a fine chemical that is used in the manufacture of a wide range of products.

Applications 5-Methyltryptamine is a methylated derivative of tryptamine. 5-Methyltryptamine is a weak antagonist of 5-Hydroxytryptamine (H974990) with weak potency as stimulants of the cardiac sympathetic nerves. 5-Methyltryptamine is also used in the preparation of inhibitors of kinesin spindle protein (KSP), a promising class of anticancer agents. References Fozard, J.R. et al.: Naun.-Schmied. Arch. Pharmacol., 301, 223 (1978); Slotkin, T. et al.: Mol. Pharmacol., 15, 607 (1979); Liu, F. et al.: Bioorg. Med, Chem., 18, 4167 (2010);