CAS 101622-51-9: Olomoucine
Formula:C15H18N6O
InChI:InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
InChI key:InChIKey=GTVPOLSIJWJJNY-UHFFFAOYSA-N
SMILES:N(CC1=CC=CC=C1)C2=C3C(=NC(NCCO)=N2)N(C)C=N3
Synonyms:- 2-(2-Hydroxyethylamino)-6-Benzylamino-9-Methylpurine
- 2-(2′-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
- 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol
- 2-[[6-(Benzylamino)-9-methylpurin-2-yl]amino]ethanol
- 2-[[9-Methyl-6[(Phenylmethyl)Amino]-9H-Purin-2-Yl]Amino]-Ethanol
- 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol
- 6-Benylamino-2-(2-Hydroxyethylamino)-9-Methylpurine
- 6-Benzylamino-2-(2-Hydroxyethylamino)-9-Methylpurine
- Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
- N2-[(2-Hydroxyethyl)]-N6-Benzyladenine
- NSC 666096
- See more synonyms
Sort by
Found 7 products.
Olomoucine-d3
CAS:Controlled ProductApplications Olomoucine-d3 is the labeled analogue of Olomoucine (O567000), A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest. References Vesely, J., et a.: Eur. J. Biochem., 224, 771 (1994), Abraham, R.T., et al.: Biol. Cell, 83, 105 (1995)Formula:C15D3H15N6OColor and Shape:NeatMolecular weight:301.36Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
CAS:Formula:C15H18N6OPurity:99%Color and Shape:SolidMolecular weight:298.343Olomoucine
CAS:Formula:C15H18N6OPurity:(as N) ≥ 98.0%Color and Shape:White to off-white powder or solidMolecular weight:298.35Olomoucine
CAS:Olomoucine is a chemical inhibitor that binds to the ATP-binding site of the enzyme cyclin-dependent kinase 2 (CDK2) and prevents its phosphorylation of retinoblastoma protein, which leads to the inhibition of cell cycle progression. Olomoucine was shown to inhibit LPS-induced inflammatory response in vitro. It also inhibits neuronal death induced by hydrogen peroxide and glutamate in vitro. The drug has been shown to inhibit axonal growth in vitro as well as tumour cell lines. Olomoucine is also an inhibitor of drug transporters, including P-glycoprotein, with potential therapeutic benefit for cancer treatment. Olomoucine binds to mitochondrial membrane potential and inhibits neurotrophic factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF).Formula:C15H18N6OPurity:Min. 95%Molecular weight:298.34 g/molRef: 3D-FO26555
Discontinued productOlomoucine
CAS:Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.Formula:C15H18N6OPurity:99.8%Color and Shape:White Crystalline PowderMolecular weight:298.34Ref: TM-T21588
1mg66.00€5mg144.00€10mg227.00€25mg455.00€50mg663.00€100mg847.00€1mL*10mM (DMSO)136.00€
![Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0004Z8.jpg&w=3840&q=75)
