CAS 101646-02-0: 3-Chloro-4-fluoro-5-nitrobenzotrifluoride

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1-Chloro-2-Fluoro-3-Nitro-5-(Trifluoromethyl)Benzene is an analog of 1-chloro-2,4,6,8-tetrafluoroanthracene. Nitrosation of the chlorinated benzene with nitric acid and hydrochloric acid in the presence of sulfuric acid gives 1,2,4,5,6,7,8-hexachlorodibenzofuran. In this reaction the chlorine atom is replaced by a nitro group. The reaction proceeds through a cyclization reaction to form a benzimidazole ring. This process is termed anomalous chlorination because it does not follow the normal pattern that would be expected for substitution reactions. The product can also be obtained by reacting the chlorinated benzene with sodium hydroxide in ethanol to give 2-[1'-chloro(trifluoromethyl)benzoy

3-Chloro-4-fluoro-5-nitrobenzotrifluoride