O-Tolyl-acetyl chloride, with the CAS number 10166-09-3, is an organic compound characterized by its acetyl chloride functional group attached to an o-tolyl group. It appears as a colorless to pale yellow liquid and has a pungent odor typical of acyl chlorides. This compound is known for its reactivity, particularly in acylation reactions, where it can introduce the acetyl group into various substrates, including alcohols and amines. O-Tolyl-acetyl chloride is soluble in organic solvents such as dichloromethane and ether but reacts with water, leading to the formation of o-tolyl-acetic acid and hydrochloric acid. Due to its reactivity, it is essential to handle this compound with care, using appropriate safety measures to avoid exposure, as it can be corrosive and irritating to the skin, eyes, and respiratory system. In synthetic organic chemistry, it serves as an important intermediate in the preparation of various pharmaceuticals and agrochemicals.

O-TOLYL-ACETYL CHLORIDE

Benzeneacetyl chloride, 2-methyl-

O-Tolyl-acetyl chloride

2-(2-Methylphenyl)acetyl chloride is a white crystalline solid that emits a strong odor. It is used in the synthesis of 2-methylbenzophenone, which is an aromatic compound. The compound undergoes regiospecific prototropic rearrangement to form ethylene, which then reacts with methyl iodide to produce an isomeric mixture of 2-(2-methylphenyl)ethanols. The resultant mixture can be separated into its two components using chromatography and recrystallization. This process is called dimerization. 2-(2-Methylphenyl)acetyl chloride has also been shown to react with sulphoxides to form heterocyclic rings.

CAS 10166-09-3: O-TOLYL-ACETYL CHLORIDE

Benzeneacetyl chloride, 2-methyl-

Ref: IN-DA00054G

O-Tolyl-acetyl chloride

Ref: 10-F014708

2-(2-Methylphenyl)acetyl chloride

Ref: 3D-KAA16609

2-(2-Methylphenyl)acetyl chloride

Ref: 54-OR311081