GW791343 (HCl) is a chemical compound that belongs to the class of small molecules, specifically designed as a selective antagonist of the chemokine receptor CCR2. This compound is notable for its potential therapeutic applications, particularly in the treatment of inflammatory diseases and conditions associated with chronic pain. As a hydrochloride salt, GW791343 exhibits enhanced solubility and stability in aqueous environments, which is advantageous for pharmaceutical formulations. The molecular structure of GW791343 includes specific functional groups that contribute to its binding affinity and selectivity for the CCR2 receptor. In terms of physical properties, it is typically characterized by its crystalline form, which can influence its bioavailability and pharmacokinetics. Safety and toxicity profiles are essential considerations in its development, and ongoing research aims to elucidate its efficacy and mechanism of action in various biological systems. Overall, GW791343 (HCl) represents a promising candidate in drug discovery, particularly in the realm of targeted therapies for inflammatory conditions.

GW791343 (HCl)

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2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride (SSR180711) is a drug candidate for the treatment of depression. It has been shown that SSR180711 enhances the effects of gamma-aminobutyric acid (GABA) in the brain by inhibiting the GABA transporter. The synergistic effect of SSR180711 with 5-hydroxytryptamine (5-HT), an important neurotransmitter in depression, was also demonstrated in experimental studies. This drug has been shown to have no effect on food intake or weight gain and is unlikely to be addictive.

2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride

GW791343 dihydrochloride

Acetamide, 2-[(3,4-difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-, hydrochloride (1:2)

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

CAS 1019779-04-4: GW791343 (HCl)

2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride

Ref: 3D-FD39560

GW791343 dihydrochloride

Ref: 54-BUP10135

Acetamide, 2-[(3,4-difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-, hydrochloride (1:2)

Ref: IN-DA00064Z

GW791343 dihydrochloride

Ref: TM-T7805