CAS: 1020399-49-8

CARM1-IN-1

CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.

CARM1-IN-1 is a selective inhibitor designed to target and inhibit the activity of coactivator-associated arginine methyltransferase 1 (CARM1). This compound is synthetically derived and specifically interacts with its enzymatic target by competitively binding to its active site, thereby preventing the methylation of arginine residues on histone and non-histone proteins. The primary mode of action of CARM1-IN-1 involves the modulation of gene expression through epigenetic regulation. By inhibiting CARM1 activity, the compound effectively alters chromatin structure and transcriptional programs, offering a research tool for understanding the role of arginine methylation in cellular processes. CARM1-IN-1 is utilized in various biological and biomedical research applications, particularly in studies related to cancer and metabolic diseases, where dysregulated arginine methylation is implicated in pathogenesis. Researchers employ this inhibitor to dissect the functional roles of CARM1 in gene expression and to explore potential therapeutic strategies for diseases associated with its overactivity.