CAS: 1020719-42-9

Applications A deuterated prodrug of Penciclovir (P221500), which is used as an antiviral. References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),

Famciclovir-d4 is a deuterium-labeled antiviral nucleoside analog, which is a synthetic derivative of the guanine analog famciclovir. This compound is sourced through advanced chemical synthesis where deuterium atoms replace specific hydrogen atoms, providing an isotopic label that aids in the tracking and analysis of the pharmaceutical compound within biological systems. Famciclovir-d4 functions primarily by inhibiting viral DNA replication. Upon administration, it is rapidly converted into its active form, penciclovir, inside the host organism. Penciclovir selectively targets and inhibits viral DNA polymerase, thereby disrupting the replication of viral DNA and curbing the proliferation of herpes viruses within the host cells. The main applications of Famciclovir-d4 are in pharmacokinetic and metabolic studies, serving as a critical tool for understanding the biochemical pathways and the in vivo dynamics of famciclovir. Its use enables researchers to study the absorption, distribution, metabolism, and excretion (ADME) of the drug with enhanced precision, contributing to insights into dosage formulation and therapeutic efficacy.