CAS: 1020719-78-1

Stability Light Sensitive Applications The isotopically labelled drug Sulfadiazine. Antibacterial. References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),

Sulfadiazine-d4 is an isotopically labeled antibiotic, which is a derivative of sulfadiazine containing four deuterium atoms. This compound is synthesized using advanced chemical techniques to replace hydrogen atoms with deuterium in the molecular structure. The mechanism of action involves inhibition of bacterial dihydropteroate synthase, an enzyme critical in the folate synthesis pathway. By preventing the production of folic acid, sulfadiazine-d4 effectively halts bacterial growth and replication. This labeled compound is primarily used in pharmacokinetic studies to track drug metabolism and distribution in biological systems. Its deuterated form offers enhanced stability and facilitates precise mass spectrometry analysis, allowing researchers to discern metabolic pathways and degradation products more accurately. Sulfadiazine-d4 is invaluable in research settings, particularly for studies requiring detailed quantification of sulfonamide antibiotics within complex biological matrices. Its use contributes significantly to understanding drug action, optimizing therapeutic regimens, and developing new antimicrobial strategies.

Sulfadiazine D4 is a deuterium labeled Sulfadiazine. Sulfadiazine used for the treatment of toxoplasmosis.