CAS 10236-14-3: Triethyl 4-phosphonocrotonate

4-(Diethoxyphosphinyl)-2-butenoic acid ethyl ester (EDEP) is a selective inhibitor of the transcription factor human leukocyte antigen-1 (HLA-1). It is a stereoselective and potent inhibitor of HIV-1, with an IC50 of 0.8 μM. EDEP has also been shown to be active against cancer cells, including HLA-A2+ breast cancer cells, HL60 leukemia cells, and human cervical cancer cells. This compound is also an inhibitor of quinolizidine alkaloids biosynthesis in plants. EDEP inhibits the synthesis of quinolizidine alkaloids by binding to the nitrogen nucleophile. EDEP can inhibit the activity of coatings that are made from polymers such as polyvinyl chloride (PVC), polyurethane, or epoxy resins.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Ethyl 4-(diethoxyphosphoryl)crotonate

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.