CAS 1025967-78-5: Lifitegrast
Formula:C29H24Cl2N2O7S
InChI:InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
InChI key:InChIKey=JFOZKMSJYSPYLN-QHCPKHFHSA-N
SMILES:ClC1=C2C(CN(C(=O)C=3C=C4C(=CC3)C=CO4)CC2)=CC(Cl)=C1C(N[C@@H](CC5=CC(S(C)(=O)=O)=CC=C5)C(O)=O)=O
Synonyms:- N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine
- Xiidra
- Lifitegrast
- L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-
- SAR 1118
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Found 11 products.
Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.48Lifitegrast
CAS:Controlled ProductApplications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer. References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);Formula:C29H24Cl2N2O7SColor and Shape:White To Off-WhiteMolecular weight:615.481L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-
CAS:Formula:C29H24Cl2N2O7SPurity:97%Color and Shape:SolidMolecular weight:615.4811Lifitegrast-d4
CAS:Controlled ProductFormula:C29D4H20Cl2N2O7SColor and Shape:NeatMolecular weight:619.506Lifitegrast
CAS:Inhibits binding of lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule 1 (ICAM-1) surface integrins. The activity of lifitegrast on these proteins at the ocular surface leads to suppressed T-cell mediated inflammatory response involved in dry eye disease. This compound also has therapeutic potential for contact lens-related corneal infiltrates.Formula:C29H24Cl2N2O7SPurity:Min. 95%Color and Shape:White/Off-White To Yellow SolidMolecular weight:614.06813
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