CAS 10268-06-1: Benzeneacetamide, 2-chloro-

2-(2-Chlorophenyl)acetamide

2-(2-Chlorophenyl)acetamide is a trisubstituted acetamide that has been shown to bind to the benzodiazepine receptor. This binding prevents the binding of GABA to the receptor and inhibits the ion channel, which leads to increased cell membrane permeability and cell death. 2-(2-Chlorophenyl)acetamide also binds to the anhydrase II isoform, which causes inhibition of carbonic anhydrase activity. This in turn leads to increased levels of carbon dioxide in some tissues, such as those found in the eye, leading to irritation and pain. The compound has also been shown to inhibit mitogen-activated protein kinase (MAPK), which is a protein involved in cellular signalling pathways that regulate growth and differentiation. It does this by preventing phosphorylation of MAPK at tyrosine residues.