CAS 10285-06-0: INTERMEDINE

Intermedine is a pyrrolizidine alkaloid, which is a secondary metabolite derived from certain plant species, particularly within the Boraginaceae family. These alkaloids are primarily isolated from the aerial parts of plants such as comfrey and other herbal species. The mode of action of Intermedine involves its bioactivation in the liver, leading to the formation of reactive metabolites that can bind to cellular macromolecules. This property underlies its cytotoxic and potentially genotoxic effects. Research into Intermedine focuses on its pharmacological and toxicological properties. Its ability to induce hepatotoxicity and hepatocarcinogenesis makes it a molecule of interest in studies related to liver damage and cancer. Additionally, its role as a chemical marker in plant extracts is significant for assessing the safety and potential risk of herbal supplements containing pyrrolizidine alkaloids. Further investigations are crucial for understanding its metabolic pathways and interactions within biological systems, which may provide insights into developing safer phytotherapy practices.

Stability Hygroscopic Applications Intermedine is an unsaturated monoester pyrrolizidine alkaloid that is extracted from the seeds of Amsinckia intermedia, a tarweed that causes enzootic hepatic cirrhosis in horses and hard liver disease in cattle. Intermedine is also a diastereomer of Lycopsamine (L487525), a pyrrolizidine alkaloid that is found in honey and in comfrey (a topical anti-inflammatory agent used to treat patients with arthritis and gout). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Culvenor, C., et al.: J. Agr. Food Chem., 29 958 (1981); Janes, D., et al.: Nat. Prod. Comm., 7, 861 (2012); Li, Y. & Stermitz, F.: J. Nat. Prod., 51, 1289 (1988); McCulloch, E.: Am. Vet. Med. Assoc., 96, 5 (1940); Pawar, R., et al.: J. Sep. Sci., 33, 200 (2010)

(+)-Intermedine, a pyrrolizidine alkaloid (PA), shows remarkable cytotoxic activity against neural progenitor cells (NPCs).

Natural alkaloid