CAS 102978-40-5: 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-

(rac)-Exatecan Intermediate 1 is a camptothecin derivative, a potential topoisomerase I inhibitor, used in tumor research.

(rac)-Exatecan Intermediate 1

4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is an organic compound that belongs to the class of pyridine. It is a semisynthetic derivative of camptothecin and has been synthesized from formamide and an aldehyde. The reaction proceeds via Wittig reaction with carbonylation as the final step. This product has been used in asymmetric synthesis for the preparation of enantiomers.