CAS 103-32-2: Benzylaniline

N-Phenylbenzylamine

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

N-Benzylaniline is an oxidation catalyst that has been shown to selectively catalyze the acylation of amines with diethyl succinate in the presence of sodium carbonate. This reaction leads to the formation of diazonium salts, which are then reacted with a hydroxyl group to form a diazo compound. The diazo compounds can be used as intermediates for the synthesis of different organic compounds. N-Benzylaniline has been shown to be a solid catalyst in flow systems, and its use is advantageous because it is less toxic than other catalysts. N-Benzylaniline also has structural features that provide insight into its reactivity, such as intramolecular hydrogen bonds and hydrochloric acid groups.

Applications N-Benzylaniline is a major metabolite of the antihistaminic Antazoline and other N-substituted benzylanilines. References Ali, H.M. et al.: J. Chrom., 202, 287 (1980); Kucukguzel, I. et al.: J. Fac. Pharm. Istan. Univ., 32, 69 (1998);

N-Phenylbenzylamine

A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization