1H-Indole-2,6-dicarboxylic acid is an organic compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. This compound features two carboxylic acid groups (-COOH) located at the 2 and 6 positions of the indole ring, contributing to its acidic properties and potential for forming hydrogen bonds. It is typically a white to off-white crystalline solid that is soluble in polar solvents such as water and alcohols, owing to the presence of the carboxylic acid groups. The compound is of interest in various fields, including medicinal chemistry and biochemistry, due to its potential biological activities and applications in synthesizing other indole derivatives. Its molecular structure allows for various chemical reactions, including esterification and amidation, making it a versatile building block in organic synthesis. Additionally, the presence of the indole moiety may impart unique pharmacological properties, making it a subject of research in drug development.

1H-INDOLE-2,6-DICARBOXYLIC ACID

103027-97-0: 6-Carboxyindole-2-Carboxylic Acid, Indole-2,6-dicarboxylic acid

1H-Indole-2,6-dicarboxylic acid (1HIDCA) is a dicarboxylic acid that is the analogue of indole-2-carboxylic acid. It has been shown to bind to DNA and inhibit the transcription of genes involved in cell division. Analogues of 1HIDCA have also been synthesized, including analogs with amino acids as linkers. These analogues have been shown to bind to DNA and inhibit transcription, but they also have different properties than 1HIDCA, such as being more hydrophilic or having a higher binding affinity for DNA. Molecular modeling has shown that 1HIDCA binds to two adjacent deoxyribose units in dna and inhibits the synthesis of proteins.

CAS 103027-97-0: 1H-INDOLE-2,6-DICARBOXYLIC ACID

1H-Indole-2,6-dicarboxylic acid

Ref: 3D-DEA02797

1H-Indole-2,6-dicarboxylic acid

Ref: 10-F064539

1H-INDOLE-2,6-DICARBOXYLIC ACID

Ref: IN-DA008RQ8