CAS 10315-07-8: 1-(Phenylmethyl)-4-piperidinecarboxylic acid

1-Benzylpiperidine-4-carboxylic acid

1-Benzyl-isonipecotic acid is a chemotactic agent that has been shown to stimulate the migration of cells in cell-free systems and in blood. It activates dopamine receptors and has been shown to have neurotoxic effects at high concentrations. 1-Benzyl-isonipecotic acid also binds to the oxadiazole pharmacophore, which is a common structural motif found in many biologically active compounds. The optimization of this molecule was achieved by linking two molecules together with a linker, which resulted in an agonistic activity against the MCP1 receptor. The homology model was created using a published crystal structure and this model was used for screening purposes. This molecule showed agonistic activity against dopamine receptors, which could be useful for treating Parkinson's disease.