CAS 1036915-08-8: 2′-C-Methylguanosine 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
Formula:C25H35N6O9PS
InChI:InChI=1S/C25H35N6O9PS/c1-24(2,13-32)22(35)42-10-9-38-41(37,28-11-15-7-5-4-6-8-15)39-12-16-18(33)25(3,36)21(40-16)31-14-27-17-19(31)29-23(26)30-20(17)34/h4-8,14,16,18,21,32-33,36H,9-13H2,1-3H3,(H,28,37)(H3,26,29,30,34)/t16-,18-,21-,25-,41?/m1/s1
InChI key:InChIKey=FGHMGRXAHIXTBM-TWFJNEQDSA-N
SMILES:C[C@]1(O)[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(NCC4=CC=CC=C4)(OCCSC(C(CO)(C)C)=O)=O)[C@H]1O
Synonyms:- 2′-C-Methylguanosine 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
- Guanosine, 2′-C-methyl-, 5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
- IDX 184
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Found 3 products.
2'-C-Methylguanosine monophosphate
CAS:2'-C-Methylguanosine monophosphate is an analog of guanosine that has been shown to inhibit the replication of viruses in vitro. It binds to the cavity present in the viral polymerase in such a way that it blocks the binding of guanosine triphosphate, which is necessary for viral replication. This drug has been shown to be toxic to cells in culture and also inhibits cellular RNA synthesis. 2'-C-Methylguanosine monophosphate has also been shown to bind to replicons as well as RNA and DNA.Formula:C25H35N6O9PSPurity:Min. 95%Molecular weight:626.6 g/molIDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formula:C25H35N6O9PSPurity:99.29%Color and Shape:SolidMolecular weight:626.62
