1H-Indazole-7-carboxylic acid, 3-bromo- is a chemical compound characterized by its indazole core, which is a bicyclic structure containing a five-membered ring fused to a six-membered ring. The presence of a carboxylic acid functional group at the 7-position contributes to its acidic properties, while the bromine substituent at the 3-position introduces halogen reactivity, which can influence its chemical behavior and reactivity in various reactions, such as nucleophilic substitutions or coupling reactions. This compound is typically used in organic synthesis and may serve as an intermediate in the production of pharmaceuticals or agrochemicals. Its molecular structure allows for potential interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the compound's solubility, stability, and reactivity can vary depending on the solvent and conditions used in experiments. Overall, 1H-Indazole-7-carboxylic acid, 3-bromo- is a versatile compound with applications in research and development within the fields of chemistry and biochemistry.

1H-Indazole-7-carboxylicacid, 3-bromo-

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3-Bromo-1H-indazole-7-carboxylic acid

3-Bromo-1H-indazole-7-carboxylic acid (3BI) is a potent and selective inhibitor of the NADPH oxidase. 3BI binds to the active site of the enzyme, preventing it from accepting electrons. It has been shown that 3BI inhibits both constitutive and inducible forms of NADPH oxidase with similar potency. The compound also shows selectivity for NADPH oxidase over other enzymes such as xanthine oxidoreductase and cytochrome P450 reductase. The inhibition of NADPH oxidase by 3BI prevents the production of reactive oxygen species, which are important in many biological processes such as signaling pathways, cell growth, and apoptosis.

CAS 1040101-01-6: 1H-Indazole-7-carboxylicacid, 3-bromo-

3-Bromo-1H-indazole-7-carboxylic acid

Ref: 10-F225077

3-Bromo-1H-indazole-7-carboxylic acid

Ref: 3D-QRB10101

3-Bromo-1H-indazole-7-carboxylic acid

Ref: 54-OR76215

3-Bromo-1H-indazole-7-carboxylic acid

Ref: IN-DA0038CK