CAS: 1048371-03-4

UPF 1069

5-Phenacyloxy-2H-isoquinolin-1-one is a synthetic chemical compound, which is primarily utilized as a biochemical inhibitor. This compound is derived from isoquinolinone sources and is distinguished by its phenacyloxy moiety linking it to the isoquinolinone core structure. Its mechanism of action involves selectively inhibiting specific biological pathways, a characteristic that makes it a valuable tool in the study of enzyme regulation and signal transduction processes. By interfering with these pathways, 5-Phenacyloxy-2H-isoquinolin-1-one provides insights into cellular functions and the biochemical landscape. In research settings, this compound is extensively applied in the exploration of therapeutic targets, particularly within the realms of cancer research and neurobiology. Scientists harness its ability to disrupt specific enzymatic activities to elucidate molecular mechanisms and identify potential intervention points for drug development. The versatility and specificity of 5-Phenacyloxy-2H-isoquinolin-1-one render it an indispensable reagent in the biochemical toolbox, facilitating advancements in molecular biology and pharmacology.

UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.