CAS 105558-26-7: Ginsenoside Rh3

Ginsenoside Rh3 is a natural product extracted from Ginseng C. A. Mey.Ginsenoside Rh3 has antifungal and antioxidant activities and induces Nrf2 activation in human retinal cells.

Applications Ginsenoside Rh3 is an inhibitor of the NLRP3 and AIM2 inflammasome activation. References Kim, J., et al.: 158, 143-150 (2014)

Ginsenoside Rh3 is a bacterial metabolite of Rg5, which is the main constituent of heat-processed ginseng, has anti-inflammatory effect in microglia by modulating AMPK and its downstream signaling pathways.

Ginsenoside Rh3 is a bioactive saponin compound, which is a principle component isolated from Panax ginseng, a perennial plant widely known for its medicinal properties. This compound represents a specific form of ginsenoside with distinct pharmacological characteristics derived through the deglycosylation process of other ginsenosides during processing or digestion. Ginsenoside Rh3 acts primarily through modulating cellular signaling pathways, influencing cell proliferation, apoptosis, and inflammation. It has been shown to interact with various molecular targets, such as inhibiting NF-κB activity and modulating MAPK pathways, which leads to its multifaceted biological effects. The applications of Ginsenoside Rh3 are diverse and significant in the biomedical and pharmaceutical fields. It is under investigation for its potential anti-cancer properties due to its ability to inhibit tumor growth and metastasis. Additionally, its anti-inflammatory and neuroprotective activities make it a candidate for studies in treating inflammatory diseases and neurodegenerative disorders. Given its broad range of biological activities, Ginsenoside Rh3 remains a focal point of research aiming to develop novel therapeutic strategies.