CAS 105628-07-7: Fasudil hydrochloride
Formula:C14H17N3O2S·ClH
InChI:InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChI key:InChIKey=LFVPBERIVUNMGV-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2)N3CCCNCC3.Cl
Synonyms:- 1-(5-Isoquinolinesulfinyl)hexahydro-1H-1,4-diazepine hydrochloride
- 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride
- 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride
- Fasudil HCL
- Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride
- Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
- Eril
- Fasudil hydrochloride
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Found 10 products.
1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride
CAS:Formula:C14H17ClN3O2SPurity:97%Color and Shape:SolidMolecular weight:327.8296Fasudil monohydrochloride, 99+%
CAS:Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C14H18ClN3O2SPurity:99+%Color and Shape:White to off-white, Powder or crystals or crystalline powderMolecular weight:327.83Fasudil Monohydrochloride Salt
CAS:Stability Hygroscopic Applications Fasudil Monohydrochloride Salt is a selective ROCK inhibitor. References Kanazawa, I., et al.: Endocr. J., 57, 415-421 (2010); Ding, J., et al.: J. Neurochem., 114, 1619-1629 (2010); Li, Y., et al.: Med. Sci. Monit., 16, BR112-BR118 (2010); Fujimura, M., et al.: Toxicol. Appl. Pharmacol., 250, 1-9 (2011);Formula:C14H17N3O2S·ClHColor and Shape:NeatMolecular weight:327.83Fasudil HCl
CAS:Formula:C14H17N3O2S·HClColor and Shape:White To Off-White SolidMolecular weight:291.37 36.46Fasudil Monohydrochloride Salt
CAS:Fasudil Monohydrochloride SaltFormula:C14H17N3O2S·ClHPurity:By hplc: 99.00% (Typical Value in Batch COA)Color and Shape: white to almost white powder to crystalsMolecular weight:327.83g/molFasudil, Monohydrochloride Salt
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:327.8299865722656Fasudil hydrochloride
CAS:Fasudil hydrochloride is a Rho-kinase inhibitor, which is a synthetic compound derived from natural sources, primarily used in scientific research. The mode of action of Fasudil hydrochloride involves the inhibition of Rho-associated protein kinase (ROCK), a crucial player in the regulation of the actin cytoskeleton. By inhibiting ROCK, Fasudil alters various cellular functions, including contraction, motility, proliferation, and apoptosis. Fasudil hydrochloride is primarily applied in neurological and cardiovascular research. It is utilized to investigate the therapeutic potential for conditions like cerebral vasospasm, ischemic stroke, and other vascular disorders. In the realm of neuroscience, it aids in studying the pathophysiological processes of neurodegenerative diseases, given its capacity to ameliorate the effects of vascular damage and enhance blood flow. Additionally, its role is being explored in areas related to hypertension and atherosclerosis. The broad applicability of Fasudil hydrochloride in diverse research areas accentuates its significance in understanding disease mechanisms and evaluating potential therapeutic interventions.Formula:C14H17N3O2S•HClPurity:Min. 95%Color and Shape:White PowderMolecular weight:327.83 g/molFasudil Hydrochloride
CAS:Formula:C14H17N3O2S·HClPurity:>96.0%(HPLC)(qNMR)Color and Shape:White to Almost white powder to crystalMolecular weight:327.83Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:100% - ≥95%Color and Shape:White SolidMolecular weight:327.83
