CAS 105628-72-6: Hydroxyfasudil
Formula:C14H17N3O3S
InChI:InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChI key:InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C1=C2C(C(=O)NC=C2)=CC=C1)N3CCCNCC3
Synonyms:- 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
- 1H-1,4-Diazepine, 1-[(1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-
- 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1(2H)-one
- 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1(2H)-one hydrochloride (1:1)
- 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
- Ha 1100
- Ha 1100 Hydrochloride
- Hydroxyfasudil
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Found 8 products.
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one
CAS:Purity:95.0%Molecular weight:307.36999511718751-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
CAS:Formula:C14H17N3O3SPurity:98%Color and Shape:SolidMolecular weight:307.36807999999996Hydroxyfasudil
CAS:Hydroxyfasudil is a drug that belongs to the group of drugs called macrophage-derived growth factor (MDGF) mimetics. It is a small molecule that can be used for the treatment of eye disorders, such as macular degeneration and diabetic retinopathy, and also for the treatment of other disorders, such as primary pulmonary hypertension and kidney fibrosis. Hydroxyfasudil binds to the protein receptor CD47 on blood cells to inhibit inflammation in mice with an inflammatory response. The drug has been shown to reduce levels of pro-inflammatory cytokines, such as IL-1β and TNFα, in mice with LPS-induced inflammatory responses. Hydroxyfasudil also inhibits pro-inflammatory cytokine production by LPS in human monocytes and blocks T cell proliferation induced by LPS in vitro.Formula:C14H17N3O3SPurity:Min. 95%Molecular weight:307.37 g/molRef: 3D-FEA62872
Discontinued productFasudil Impurity 5
CAS:Formula:C14H17N3O3SColor and Shape:White To Off-White SolidMolecular weight:307.375-((1,4-Diazepan-1-Yl)Sulfonyl)Isoquinolin-1(2H)-One
CAS:5-((1,4-Diazepan-1-Yl)Sulfonyl)Isoquinolin-1(2H)-OnePurity:98%Molecular weight:307.37g/molHydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formula:C14H17N3O3SPurity:98.13%Color and Shape:SolidMolecular weight:307.37
![1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA008RE1.jpg&w=3840&q=75)
