CAS 10596-32-4: difluoromethylene diphosphonate

Difluoromethylenediphosphonic acid is a prodrug that is activated by the addition of fluoride ions. It inhibits tyrosine phosphatases, which are enzymes that catalyze the hydrolysis of phosphate groups from proteins. Difluoromethylenediphosphonic acid is also an analog of vitamin B1 and has been shown to inhibit insulin sensitivity in animals. Difluoromethylenediphosphonic acid can be used as a linker for peptide-based drugs and has optical properties that make it useful in biochemistry applications such as DNA sequencing, detection of single nucleotide polymorphisms (SNPs), and homology modeling.

Stability Hygroscopic Applications A phosphonic acid derivative for development of biologically active compounds. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ma, Q.F., et al.: Biochemistry, 29, 1412 (1990), Soti, C., et al.: Eur. J. Biochem., 270, 2421 (2003), Barabas, O., et al.: J. Biol. Chem., 279, 42907 (2004),