6-Iodo-uridine is a modified nucleoside that features an iodine atom substituted at the 6-position of the uridine molecule, which is a pyrimidine nucleoside composed of a uracil base and a ribose sugar. This compound is characterized by its potential applications in biochemical research and medicinal chemistry, particularly in the study of nucleic acid interactions and antiviral activity. The presence of the iodine atom can influence the compound's biological properties, including its stability, solubility, and interaction with enzymes and receptors. 6-Iodo-uridine may also exhibit unique spectroscopic properties due to the halogen substitution, making it useful in various analytical techniques. Additionally, its structural modification can affect its incorporation into RNA, providing insights into RNA metabolism and function. Overall, 6-iodo-uridine serves as a valuable tool in the exploration of nucleoside analogs and their roles in biological systems.

6-iodo-uridine

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6-Iodo-uridine

6-Iodo-uridine is an antiviral drug that is used to treat tuberculosis, influenza, and hepatitis. It has a propionyl group in place of the hydroxyl group on the pyrimidine ring. This substitution stabilizes the molecule and prevents it from being broken down by enzymes in the body. 6-Iodo-uridine can be synthesized from uridine through a cross-coupling reaction with formaldehyde and propionaldehyde. 6-Iodo-uridine can also be synthesized by coupling orotic acid 5′ monophosphate decarboxylase with formaldehyde.

CAS 105967-11-1: 6-iodo-uridine

6-Iodo-uridine

Ref: IN-DA008UA5

6-Iodo-uridine

Ref: 3D-FI153253