CAS 1067-71-6: Diethyl(2-oxopropyl)phosphonate

Diethyl acetylmethylphosphonate is used as ligand in coordination chemistry to prepare lanthanide series metals like terbium, europium and neodymium. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diethyl(2-oxopropyl)phosphonate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diethyl 2-oxopropylphosphonate (DEP) is an aliphatic methylating agent that reacts with nucleophilic groups on the cell surface. It is a highly reactive chemical, which can cause adverse reactions in cells including necrosis and cytotoxicity, as well as induce DNA damage. DEP has been shown to inhibit the proliferation of leukemia cells, but not of normal cells. This agent also has fatty acid methylating properties and can be used to produce a variety of amines.