Amyloid beta-protein fragment 1-28, often referred to as Aβ(1-28), is a peptide derived from the amyloid precursor protein (APP) and is primarily associated with Alzheimer's disease. This fragment is part of a larger family of amyloid beta peptides, which are known to aggregate and form plaques in the brains of individuals with Alzheimer's. Aβ(1-28) consists of 28 amino acids and is characterized by its hydrophobic nature, which contributes to its propensity to misfold and aggregate. The peptide plays a crucial role in neurodegenerative processes, influencing neuronal toxicity and inflammation. Its structure includes regions that can form beta-sheet conformations, which are significant for aggregation. The CAS number 109770-29-8 uniquely identifies this specific fragment in chemical databases, facilitating research and study. Understanding the characteristics of Aβ(1-28) is essential for developing therapeutic strategies aimed at mitigating its pathological effects in neurodegenerative diseases.

amyloid B-protein fragment 1-28

109770-29-8: Amyloid .beta.-Protein (1-28), H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH, Beta-Amyloid(1-28), Abeta 1-28

The remarkable histochemical features of Alzheimer’s disease (AD) are plaques that contain cores of extracellular filaments, which have been identified as amyloid substance. The major component of this amyloid is the β-protein. The synthetic peptide, having the same sequence as the N-terminal 28 residues, formed fibrils that have the same antigenic and structural features like the native AD amyloid filaments.

Amyloid β-Protein (1-28)

Amyloid β-Protein (Human, 1-28) is a peptide that belongs to the group of research tools. It is an activator of ion channels and can be used as a research tool for Life Science, Cell Biology, and Pharmacology. Amyloid β-Protein (Human, 1-28) has been shown to regulate the interactions between proteins with its receptor or ligand. This protein has also been shown to inhibit the activity of ion channels and may be useful in treating diseases such as Alzheimer's disease. The chemical formula for this peptide is C17H22N4O2 and its molecular weight is 368.4 g/mol.

Amyloid β-Protein (Human, 1-28)

β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding.

CAS 109770-29-8: amyloid B-protein fragment 1-28

Amyloid β-Protein (1-28)

Ref: 01-4025511

Amyloid β-Protein (Human, 1-28)

Ref: 3D-PAB-4481-V

β-Amyloid (1-28)

Ref: TM-TP1226