CAS 110-12-3: 5-Methyl-2-hexanone

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

5-Methyl-2-hexanone

5-Methyl-2-hexanone (5ME) is a hydroxyl group containing compound that is used as a glycol ether in the synthesis of polyester and acrylic resins. It is also used as a solvent for lacquers, nitrocellulose, and cellulose acetate. 5ME has been detected in the urine of people who have been exposed to high levels of light, such as welders or those who work with photographic film. 5ME can be absorbed through skin and can cause irritation, dermatitis, and sensitization reactions. When applied to the proximal tubules of rats it produced renal damage that was attributed to its reactive properties.

Applications 5-Methyl-2-hexanone is used in the preparation od S1P1 receptor agonists. Also used in the preparation of indoles in an efficient synthesis involving the use of TCT (2,4,6-trichloro-1,3,5-triazine). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bolli, M. et al.: J. Med. Chem., 57, 78 (2014); Siddalingamurthy, E. et al.: Tetrahedron Lett., 54, 5591 (2013);