CAS: 1101810-02-9

AZD3147 is a small molecule that inhibits leukemia inhibitory factor (LIF) and consequently prevents the proliferation of pluripotent stem cells. It can be used to treat cancer and other diseases where LIF is an important factor. AZD3147 has been shown to have a high affinity for the LIF receptor and low affinity for other receptors, which helps to reduce its potential side effects. In addition, this drug has physicochemical properties that allow it to cross the blood-brain barrier. The pharmacokinetics of AZD3147 in animals have been studied at nanomolar concentrations, showing promising results.

AZD 3147

AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).