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CAS 11056-06-7: Bleomycin

Formula:Unspecified
InChI:InChI=1/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1
Synonyms:
  • Blenamax
  • Bleo
  • Bleo-Kyowa
  • Bleocin
  • Bleomycins
  • Nsc 125066
  • [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-(4-guanidinobutylcarbamoyl)thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(3H-imidazol-4-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate
  • (3-{[(2'-{(5S,8S,9S,10R,13S)-15-{6-amino-2-[(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl]-5-methylpyrimidin-4-yl}-13-[(R)-{[3-{[4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-5-[(1R)-1-hydroxyethyl]-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-2,4'-bi-1,3-thiazol-4-yl)carbonyl]amino}propyl)(dimethyl)sulfonium (non-preferred name)
  • N1-(3-(dimethylsulfonio)propyl)bleomycinamide) (Bleomycin A2)
  • BLM
  • Blenoxane
  • See more synonyms
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Found 3 products.
  • CymitQuimica logo
    Targetmol
    + Info

    Bleomycin Free Base

    CAS:
    Bleomycin Free Base, a glycopeptide antibiotic, halts DNA function and treats solid tumors.
    Formula:C55H84N17O21S3
    Color and Shape:Solid
    Molecular weight:1415.55

    Ref: TM-T71445

    25mg
    9,140.00€
    50mg
    12,142.00€
    100mg
    17,765.00€
  • Bleomycin Sulfate (mixture)
    TCI
    + Info

    Bleomycin Sulfate (mixture)

    CAS:
    Purity:>85.0%(HPLC)
    Color and Shape:White to Light yellow powder to crystal

    Ref: 3B-B3972

    10mg
    162.00€
    50mg
    608.00€
  • Bleomycin
    Biosynth
    + Info

    Bleomycin

    CAS:
    Bleomycin is an antineoplastic antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing strand breaks through the generation of free radicals, particularly in regions rich in guanine and cytosine. This leads to inhibition of DNA synthesis and, consequently, cellular replication, making it effective in targeting rapidly dividing cancer cells. The primary applications of Bleomycin are in the treatment of various cancers, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, and certain types of squamous cell carcinomas. Due to its ability to cause DNA damage, Bleomycin is often part of combination chemotherapy regimens, enhancing the overall treatment efficacy while attempting to minimize drug resistance. Understanding its biochemical interactions at a molecular level is crucial for optimizing its use and managing its potential pulmonary toxicity, a known adverse effect that requires careful patient selection and monitoring during treatment.
    Formula:C55H84N17O21S3
    Purity:Min. 95%
    Molecular weight:1,415.56 g/mol

    Ref: 3D-AB30158

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