CAS 11115-82-5: Enduracidin

Polypeptide antibiotic used as a feed additive

Enduracidin (Enramycin) is a polypeptide antibiotic produced by Streptomyces fungicides.

Enduracidin hydrochloride is an antimicrobial compound, which is a lipopeptide antibiotic derived from the genus Streptomyces, specifically Streptomyces fungicidicus or Streptomyces roseosporus. The compound exerts its antimicrobial activity by inhibiting the synthesis of bacterial cell walls, primarily targeting the lipid II cycle, a critical precursor in the peptidoglycan synthesis pathway. This inhibition disrupts the construction of peptidoglycan layers, ultimately leading to bacterial cell lysis and death. Enduracidin hydrochloride is primarily utilized in research settings to study bacterial cell wall synthesis and resistance mechanisms. It is particularly valuable in investigating Gram-positive bacterial pathogens, where its mode of action offers insights into potential therapeutic interventions. Due to its specificity and potency, enduracidin hydrochloride remains a significant focus in the development of new antibiotic formulations and the exploration of synergistic effects with other antimicrobial agents.