CAS 1117-71-1: Methyl 4-bromo-2-butenoate

It is a useful synthetic intermediate. It was used in the synthesis of irreversible inhibitors of EGFR and HER-2 tyrosine kinases with enhanced antitumor activities. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Methyl 4-bromocrotonate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Methyl 4-bromocrotonate is a conjugate of methyl 4-bromocrotonate and diethyl succinate that has been synthesized in the laboratory. This compound can be used for the treatment of cancer. Methyl 4-bromocrotonate reacts with hydroxyl groups, such as those on DNA, to form covalent bonds. The reaction yield is high and there are no byproducts. Methyl 4-bromocrotonate has a low toxicity and can be used in combination with other anticancer drugs like piperazine, which inhibits cancer cell growth by inhibiting protein synthesis. The synthesis of benzofuran derivatives requires the use of sodium sulfide as a catalyst.