CAS 1118-02-1: trimethylsilyl isocyanate

Trimethylsilyl isocyanate is used in the preparation of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones. It finds application in the carbamoylation of aromatic hydrocarbons and alcohols. It is also used in the preparation of primary amides from Grignard reagents. Further, it is used in the synthesis of cyclic imides. It is also utilized for the synthesis of trifluoroacetyl isocyanate and cyclic imides. In addition to this, it is employed in the conversion of isocyanates to carbodiimides using cyclopentadienyl Mn(CO)3 catalysis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Trimethylsilyl isocyanate (TMISC) is a 5-membered heteroaryl. It has been shown to bind to the receptor and shows activity in vitro. TMISC has been reported as a potential drug for bowel disease, congestive heart, and inflammatory bowel disease. TMISC binds to the protein receptor with high affinity, but its binding affinity decreases when it is combined with trifluoroacetic acid or palladium-catalyzed coupling. TMISC can be used to synthesize degarelix acetate, which is an anti-androgen drug that is used in the treatment of prostate cancer.