CAS 1118-61-2: 3-Amino-2-butenenitrile

3-Aminocrotononitrile

3-Aminocrotononitrile reacts with ferrocenyl-1,2-enones to form ferrocenyl pyridines. It undergoes diazotization coupling reaction with p-substituted anilines to give 2-arylhydrazone-3-ketimino-butyronitriles.3-Aminocrotononitrile, (E)+(Z), is used in reaction with aryldiazonium salts gave, instead of the expected triazene, 2-arylhydrazono-3-ketobutyronitrile by electrophilic attack at the ?-carbon and hydrolysis of the resulting imine. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. 3-Aminocrotononitrile was used as bisnucleophilic reagent which on cyclocondensation with hexafluoroacetone(ethoxycarbonylimine) forms bis(trifluoromethyl)pyrimidinones. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3-Aminocrotononitrile is a synthetic chemotherapeutic agent that inhibits the growth of cancer cells. It prevents the synthesis of DNA, RNA and proteins. 3-Aminocrotononitrile binds to the active methylene group on the DNA molecule, blocking DNA synthesis and preventing replication. It also inhibits protein synthesis by binding to the amino groups on ribosomes. 3-Aminocrotononitrile is metabolized into an enolate anion, which reacts with chloride ions to form a diacetonitrile linkage between two nitrogen atoms of the compound. This reaction produces ethylene diamine as a byproduct.