CAS 111917-59-0: Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI)

Adenanthin, a natural inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells.

Adenanthin is a natural diterpenoid compound, which is derived primarily from plants within the genus Isodon. This compound is obtained through the extraction and purification processes involving the aerial parts of these medicinally significant plants. Adenanthin exhibits its biological effects primarily through the modulation of oxidative stress pathways and the induction of apoptosis in certain cell lines. It specifically targets key redox-sensitive cysteine residues, thereby selectively inhibiting peroxiredoxin I and II. These actions result in the accumulation of reactive oxygen species (ROS), ultimately leading to the selective induction of apoptosis in cancerous cells, while sparing most non-cancerous cells. With its unique mode of action, Adenanthin is currently being researched for its potential applications in cancer therapy. Its ROS-modulating properties make it a promising candidate for targeting various malignancies, offering a novel therapeutic approach against resistant cancer types. Moreover, ongoing studies are exploring its potential role in modulating immune responses and treating autoimmune diseases. By providing insight into its mechanism, Adenanthin underscores the importance of natural compounds in drug discovery and the development of innovative therapeutic strategies.