CAS 112-67-4: Palmitoyl chloride

Stability Moisture Sensitive Applications Palmitoyl Chloride was used as a polymeric carriers for plasmid DNA (pDNA) delivery to 293T cells. References Remant, B.K.C., et al.: J. Biomaterials. Sci. Poly. Ed., 22, 873 (2011); Allard, E., et al.: Int. J. Pharma., 379, 217 (2009);

Palmitoyl chloride is a compound which has been used as a polymeric carrier for plasmid DNA delivery to 293T cells. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Palmitoyl chloride is a chemical compound that has the chemical formula CH3(CH2)16COCl. It is an ester of palmitic acid and chloroform. Palmitoyl chloride has a phase transition temperature of 39°C, giving it high resistance to heat. It can be used as a model system for studying the interactions between hydroxyl groups and chloride ions in water. This compound also has high water permeability and water vapor permeability, making it useful in the treatment of infectious diseases such as malaria. Palmitoyl chloride can be synthesized by reacting sodium carbonate with trifluoroacetic acid, which generates sodium trifluoroacetate. The sodium trifluoroacetate can react with 4-chlorobutyl alcohol to form 4-chlorobutylchloroformate, which reacts with palmitic acid to form palmitoyl chloride.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Palmitoyl chloride

Applications Palmitoyl-d31 Chloride is an intermediate in the synthesis of Glycidyl Palmitate-d31 (G615952). Unlabelled Glycidyl Palmitate (G615950) is used for preparation of lysophosphatidic acids which inhibit apoptosis. References Mills, G.B., et al.: Nat. Rev. Cancer., 3, 582 (2003); Zhang, C., et al.: J. Exp. Med., 199, 763 (2004), Lee, C.W., J. Biol. Chem., 281 (2006)