CAS 112811-59-3: Gatifloxacin

Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.

Applications An antibacterial. References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),

Gatifloxacin

Gatifloxacin hydrochloride is the salt form of gatifloxacin, which is a fluoroquinolone antibiotic that inhibits the DNA gyrase enzyme, an enzyme essential for bacterial replication. Gatifloxacin has been shown to be more active against drug-resistant strains of tuberculosis than other antibiotics. Gatifloxacin also inhibits methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, the bacteria responsible for respiratory infections. The mechanism of action of Gatifloxacin is by blocking the function of the enzyme topoisomerase II, and thus DNA replication in bacteria.

1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic a

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Gatifloxacin is an antibiotic, which is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. Its source lies in its chemical synthesis, designed to inhibit bacterial enzymes necessary for DNA replication. The mode of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, which are critical enzymes for bacterial DNA replication, transcription, and repair. This dual inhibitory mechanism disrupts bacterial cell division and growth, leading to the eventual eradication of susceptible bacterial strains. Gatifloxacin is primarily used in the treatment of a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and conjunctivitis. Given its broad-spectrum activity, it is effective against both Gram-positive and Gram-negative bacteria. This makes it a valuable asset in clinical settings where the exact bacterial pathogen may not be immediately known, allowing for empirical therapy that can be adjusted once pathogen-specific information is available. Due to its powerful antibacterial capabilities, Gatifloxacin is a critical compound in the arsenal against bacterial infections, especially those that may exhibit resistance to other antibiotic classes.

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