5'-Deoxy-4',5-difluorouridine is a nucleoside analog characterized by the presence of fluorine substituents at the 4' and 5' positions of the ribose sugar moiety. This compound is derived from uridine, where the hydroxyl group at the 5' position is replaced by a deoxy group, and the 4' and 5' positions are modified with fluorine atoms. The introduction of fluorine enhances the compound's stability and can influence its biological activity, making it of interest in medicinal chemistry, particularly in antiviral and anticancer research. The structural modifications can affect the nucleoside's ability to interact with nucleic acids and enzymes, potentially leading to altered metabolic pathways. As a nucleoside analog, it may interfere with nucleic acid synthesis, thereby exhibiting therapeutic potential. Its CAS number, 113548-97-3, is a unique identifier that facilitates the identification and study of this compound in scientific literature and databases. Overall, 5'-deoxy-4',5-difluorouridine represents a significant area of research in the development of novel therapeutic agents.

5'deoxy-4',5-difluorouridine

113548-97-3: 4'-F-5'-Dfurd, 5'-Deoxy-5-fluoro-4'-C-fluorouridine, Uridine, 5'-deoxy-5-fluoro-4'-C-fluoro-, 5-fluoro-1-(5-fluoro-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (non-preferred name)

5-Fluoro-1-(5-fluoro-3,4-dihydroxy-5-methyloxolan-2-yl)pyrimidine-2,4-dione is a prodrug that is converted to 5-fluorocytosine in the body by the enzyme uridine phosphorylase. It is used as an anti cancer drug. 5Fluorouracil inhibits the synthesis of RNA and DNA, which are essential for cell growth. It also inhibits protein synthesis in cells by competing with uridine for incorporation into RNA during the process of transcription. 5Fluorouracil has been shown to be effective against L1210 leukemia cells and some other types of cancer cells.

CAS 113548-97-3: 5'deoxy-4',5-difluorouridine

5-Fluoro-1-(5-Fluoro-3,4-Dihydroxy-5-Methyloxolan-2-Yl)Pyrimidine-2,4-Dione

Ref: 3D-FF99812

Uridine, 5'-deoxy-5-fluoro-4'-C-fluoro- (9CI)

Ref: IN-DA0008Y8