CAS 113886-72-9: 2′-O-Methyl-2-thiouridine
Formula:C10H14N2O5S
InChI:InChI=1S/C10H14N2O5S/c1-16-8-7(15)5(4-13)17-9(8)12-3-2-6(14)11-10(12)18/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,18)/t5-,7-,8-,9-/m1/s1
InChI key:InChIKey=WARUUAMZJXEUEA-ZOQUXTDFSA-N
SMILES:O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=S)NC(=O)C=C2
Synonyms:- 2′-O-Methyl-2-thiouridine
- Uridine, 2′-O-methyl-2-thio-
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Found 4 products.
2'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Formula:C10H14N2O5SPurity:99.89%Color and Shape:SolidMolecular weight:274.292'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine is a modified nucleoside that is categorized as a mismatched nucleotide. It is found in RNA, where it replaces uridine and acts as a mismatch base. 2'-O-Methyl-2-thiouridine has been shown to stabilize duplex DNA against thermal denaturation by forming triplexes with complementary sequences. It also stabilizes dsDNA against hydrolysis by the enzyme ribonuclease H (RNase H) and has been used in the design of antisense therapeutics. Thermophilic bacteria use this molecule to synthesize their own thymine nucleotides, which are structurally similar to 2'-O-methyl-2-thiouridine. This modification prevents mismatches in their own dna and helps protect them from heat stress. The thermodynamic stability of this molecule has been calculated using an algorithm that takes into account the hybridization free energy, enthalpy change, entropyFormula:C10H14N2O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:274.29 g/mol
